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Liver X receptor expression in human melanocytes, does it have a role in the pathogenesis of vitiligo?
Author(s) -
Kumar Ravinder,
Parsad Davinder,
Kaul Deepak,
Kanwar Amrinderjit
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2009.00940.x
Subject(s) - vitiligo , liver x receptor , pathogenesis , biology , nuclear receptor , transcription factor , melanocyte , cancer research , receptor , gene , endocrinology , immunology , genetics , melanoma
Vitiligo is a common, non‐contagious disorder. The basic pathogenesis of vitiligo generally, or for any of the putative subsets of vitiligo, remains unknown. The liver X receptors (LXRs), LXR‐ α and LXR‐ β are members of the nuclear hormone receptor superfamily of ligand‐activated transcription factors. Important genes involved in regulation of melanocytes are target genes of LXRs; it can be speculated that LXRs might be playing an important role in pathogenesis of pigmentary disorders. We have demonstrated in this study that there is expression of LXR‐ α / β by human melanocytes at both transcriptional and translational levels. Our present data also revealed that the expression of LXR‐ α at both mRNA and protein level was significantly higher in perilesional skin as compared to the normal skin of vitiligo patient.