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Evaluation of radiation‐induced hair follicle apoptosis in mice and the preventive effects of fibroblast growth factor‐1
Author(s) -
Nakayama Fumiaki,
Hagiwara Akiko,
Kimura Miho,
Akashi Makoto,
Imamura Toru
Publication year - 2009
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2009.00849.x
Subject(s) - hair follicle , apoptosis , follicle , in vivo , endocrinology , pathological , medicine , biology , andrology , genetics
Radiation‐induced hair loss is a clinically important, but under‐researched topic. The aim of the study was to develop an in vivo assay system for radiation‐induced apoptosis in hair follicles to promote hair research and exploit new radioprotectors. BALB/c mice received total body irradiation (TBI) with γ‐rays at doses in the range from 8 to 16 Gy at 6 days after depilation. Pathological changes were detected progressively in the hair follicles over the time course after TBI and the dystrophy was evaluated on the basis of stage‐specific parameters reported previously, which were found to be well‐suited for classification of the radiation‐induced hair follicle dystrophy. As a result, regression from anagen to catagen was determined in these follicles after irradiation. In addition, radiation‐induced apoptosis was a good early dystrophic parameter. In this system, it was found that fibroblast growth factor‐1 effectively prevented hair follicle apoptosis in mice.