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Expression of oestrogen‐related receptor alpha in human epidermis
Author(s) -
Bertil Elodie,
Bolzinger MarieAlexandrine,
André Valérie,
Rousselle Patricia,
Damour Odile
Publication year - 2008
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2007.00644.x
Subject(s) - epidermis (zoology) , receptor , immunohistochemistry , human skin , biology , alpha (finance) , blot , messenger rna , reverse transcription polymerase chain reaction , real time polymerase chain reaction , nuclear receptor , reverse transcriptase , endocrinology , medicine , microbiology and biotechnology , polymerase chain reaction , transcription factor , gene , genetics , immunology , anatomy , construct validity , nursing , patient satisfaction
Abstract: Skin is a non‐classical target for oestrogens. Despite evidence showing that oestrogen receptors (ER) are expressed in skin, there are still extensive gaps in our understanding of how oestrogens exert their action in non‐reproductive tissues. Oestrogen‐related receptor‐α (ERRα), orphan member of the nuclear receptor superfamily, shows a strong sequence homology with ERα but it does not bind oestradiol. Here, for the first time, we demonstrate ERRα expression in the epidermis of adult human skin. ERRα mRNA was detected in the epidermis of eight female donors using reverse transcriptase polymerase chain reaction. The presence of the protein was confirmed using western blotting and immunohistochemistry on 5 and 11 adult human skins, respectively. This study shows that ERRα is expressed in human epidermis and could intervene in a potentially new oestrogen signalling pathway in the skin.