Premium
Cytokine gene polymorphisms in hepatitis C virus‐related oral lichen planus
Author(s) -
Carrozzo Marco,
Dametto Ennia,
Fasano Maria Edvige,
Arduino Paolo,
Bertolusso Giorgio,
Uboldi de Capei Federica,
Rendine Sabina,
Amoroso Antonio
Publication year - 2007
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2007.00577.x
Subject(s) - oral lichen planus , hepatitis c virus , genotype , hepatitis c , single nucleotide polymorphism , cytokine , immunology , medicine , snp , hepacivirus , heterozygote advantage , virus , biology , gene , genetics
Cytokine polymorphisms may influence both the risk of developing oral lichen planus (OLP) and the outcome of hepatitis C virus (HCV)‐infected patients and OLP has been frequently associated with HCV infection. The aim of the present study was to analyse whether cytokine polymorphisms may influence the susceptibility to HCV‐related OLP. Thirty‐five patients with OLP and chronic HCV infection (OLP–HCV+ve) took part in the study. As controls, 44 patients with OLP but without HCV (OLP–HCV−ve) infection and 140 healthy donors were studied. Thirteen cytokine genes with 22 single nucleotide polymorphisms (SNP) were studied. IFN‐γ UTR 5644 genotype frequencies showed an increase in number of A/T heterozygote in OLP–HCV+ve patients compared with OLP–HCV−ve that approached the statistical significance [ P = 0.03, P‐ corrected (PC) = 0.66]. Contrarily, in OLP–HCV+ve patients, the frequency of genotype −308 G/A of the TNF‐α was decreased, whereas the genotype −308 G/G was increased compared with OLP–HCV−ve ( P = 0.0005, PC = 0.011 and P = 0.0016, PC = 0.0352, respectively). OLP patients with and without HCV infection showed a different genetic cytokine background suggesting distinct pathogenetic mechanisms.