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Anchorless keratinocyte survival: an emerging pathogenic mechanism for squamous cell carcinoma in recessive dystrophic epidermolysis bullosa
Author(s) -
Rodeck Ulrich,
Fertala Andrzej,
Uitto Jouni
Publication year - 2007
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2007.00563.x
Subject(s) - epidermolysis bullosa , keratinocyte , basal cell , cancer research , cell , dermatology , biology , medicine , pathology , cell culture , genetics
Squamous cell carcinomas in patients sufering from recessive dystrophic epidermolysis bullosa are highly invassive and frequently metastatic. Expression of a collagen VII fragement (NC1) has been described as a prerequisite for the development of this tumor form. This commentary focuses on potential molecular mechanisms by which expression of the NC1 fragment may augment anchorage‐independent growth and survival of malignant keratinocytes.