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Putative cancer stem cells in cutaneous malignancies
Author(s) -
Kamstrup Maria R.,
Gniadecki Robert,
Skovgaard Gunhild L.
Publication year - 2007
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2007.00547.x
Subject(s) - cancer stem cell , stem cell , medicine , skin cancer , cancer , cancer research , lymphoma , melanoma , cancer cell , breast cancer , cell of origin , pathology , oncology , biology , genetics
Recent experimental data offer convincing evidence for the existence of cancer stem cells in leukaemia, brain tumors and breast cancer. These cells are responsible for the maintenance of tumor growth and relapses after cytoreductive treatments. This paper provides a brief overview of current data supporting the idea of cancer stem cells in the pathogenesis of cutaneous malignancies, including skin carcinoma, malignant melanoma and cutaneous T‐cell lymphoma. The characterization of putative cancer stem cells is important to develop new therapies selectively targeting these cells.