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Signal transduction in keratinocytes
Author(s) -
Mitev V.,
Miteva L.
Publication year - 1999
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1999.tb00355.x
Subject(s) - signal transduction , phosphorylation , microbiology and biotechnology , protein kinase c , mapk/erk pathway , kinase , tyrosine phosphorylation , biology , chemistry
Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and their proliferation and differentiation are stimulated by a variety of biological factors. The major mechanism by which cells (keratinocytes) re‐spond to extracellular signals, is changing in protein phosphorylation. The protein phosphorylation is a consequence of the ligand/receptor bind‐differentiation ing which leads to activation of several transduction systems. In this re‐view we emphasize on different signal transduction pathways in kera‐ tinocytes (tyrosine kinases, PKA, PKC, MAPK, casein kinase 2 etc.).