Premium
Unusual wrinkle formation after temporary skin fixation followed by UVB irradiation in hairless mouse skin
Author(s) -
Takema Yoshinori,
Fujimura Tsutomu,
Ohsu Hiroyuki,
Imokawa Genji
Publication year - 1996
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1996.tb00109.x
Subject(s) - wrinkle , hairless , irradiation , fixation (population genetics) , groove (engineering) , skin repair , dermatology , chemistry , anatomy , medicine , surgery , materials science , wound healing , composite material , biochemistry , physics , nuclear physics , metallurgy , gene
Generally, many wrinkles form on the human face, and temporary wrinkles eventually become permanent. We evaluated the effects of temporary skin fixation on wrinkle formation after UVB irradiation using the back skin of hairless mice. In the group treated with UVB irradiation immediately after production using cyanoacrylate resin of an artificial groove parallel to the midline, wrinkles formed parallel to the midline, an uncommon direction for wrinkle formation in this mouse model. These wrinkles did not disappear even when the skin was stretched. No such changes were observed in the group in which only the temporary groove alone was produced without UVB irradiation. In 3‐D surface parameter analysis, all roughness parameters in the group treated with UVB irradiation immediately after production of an artificial groove were significantly increased relative to the age‐matched control group. In contrast, no differences were observed between the group in which only the temporary groove alone was produced without UVB irradiation and age‐matched controls. The results of this study suggest that both a temporary groove in the skin and UVB irradiation are necessary for wrinkle formation in the back skin of hairless mice.