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Porphyrin concentrations in various human tissues
Author(s) -
Goerz Günter,
LinkMannhardt Andrea,
Bolsen Klaus,
Zumdick Matthias,
Fritsch Clemens,
Schürer Nanna Y.
Publication year - 1995
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1995.tb00248.x
Subject(s) - porphyrin , chemistry , biochemistry
We measured the concentrations of total porphyrins and their metabolites (uro‐, hepta‐, hexa‐, penta‐, copro‐ and protoporphyrin) in various human tissues: liver, erythrocytes, skin, adipose tissue, and mammary gland. The porphyrin concentrations varied within minor limits, e.g., 3.1 ±2.3 nmol porphyrins/g liver and 0.50±0.10 nmol/g erythrocytes. No significant differences were detectable in other tissues in comparison with liver. In all tissues, the predominant metabolite was protoporphyrin, followed by coproporphyrin, whereas only low concentrations of higher carboxylatcd porphyrins such as uroporphyrin were detectable. It is concluded that porphyrin metabolism and its regulation is similar in all human tissues, perhaps with some small differences in the erythrocytes.