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T lymphocyte chemotaxis and skin diseases
Author(s) -
Jinquan Tan,
ThestrupPedersen Kristian
Publication year - 1995
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1995.tb00206.x
Subject(s) - chemotaxis , chemokine , lymphocyte , homing (biology) , microbiology and biotechnology , immunology , motility , lymphocyte homing receptor , biology , t lymphocyte , intracellular , extracellular , cell adhesion , cell , immune system , biochemistry , receptor , ecology
Recent advances in our understanding of the mechanisms of T lymphocyte motility and chemotaxis, particularly in aspects of lymphocyte‐endothelial adhesion, transendothelial cell migration, and T‐lymphocyte response to chemotactic gradients have contributed to our knowledge of how T lymphocytes accumulate during the initiation, the development and the control of inflammatory skin responses. In this review, we will summarize the present situation of studies on T lymphocyte adhesion and chemotaxis. The 3 major steps in T lymphocyte chemotaxis, e.g., recognition of extracellular chemotactic gradients, transduction into ap‐propriate intracellular signals, and generation of motion, will be out‐lined. Skin‐homing T lymphocytes, chemokines and other chemoattractants will also be discussed in relation to skin diseases.