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γ‐melanocyte stimulating hormone (γ‐MSH)‐like immunoreactivity is present in certain normal human keratinocytes
Author(s) -
Johansson Ollc,
Liu Peng
Publication year - 1993
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1993.tb00034.x
Subject(s) - stratum spinosum , stratum corneum , immunohistochemistry , melanocyte stimulating hormone , epidermis (zoology) , melanocyte , epithelium , endocrinology , medicine , keratinocyte , hormone , sweat , biology , chemistry , pathology , anatomy , cell culture , cancer research , melanoma , genetics
Using ihe indirect immunohistochemical approach, the occurrence of γ‐melanocyte stimulating hormone (γ‐MSH)‐like immunoreactivily in human normal keratinocytes is described. The positive cells were observed in each layer of the epidermis (except stratum corneum) and often, at the level of the stratum spinosum, also around the orifices of cutaneous accessory organs, such as sweat glands and sebaceous glands/ hair follicles. Combining these data with our previous investigations, the results support the possibility that locally produced γ‐MSH could be involved in cutaneous immune response, pigmentation and epithelial pro‐liferation, as well as neuromodulation.