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Demonstration of the high‐affinity IgE receptor (FcɛRI) on Langerhans cells of oral mucosa
Author(s) -
Haas N.,
Hamann K.,
Grabbe J.,
Czarnetzki B. M.
Publication year - 1993
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1993.tb00025.x
Subject(s) - immunoglobulin e , chemistry , receptor , langerhans cell , fc receptor , immunology , medicine , antigen , antibody , biochemistry
Langerhans cells in the skin have recently been shown to bind IgE molecules via a high‐affinity IgE receptor. Using two specific antibodies, 29C6 and 6F7, against the α‐chain of the high‐affinity IgE receptor we here demonstrate that Langerhans cells express this receptor in oral mucosa. A specific antibody. Tül, against the low‐affinity IgE receptor showed only low expression of this receptor. High‐affinity binding for IgE may be important for induction and support of Langerhans cell‐dependent transepithelial IgE‐mediated allergic reactions and inflammation.