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Increased polymorphonuclear leukocyte Fc gamma‐dependent chemiluminescence in active psoriasis is not related to FcRIII (CD 16) receptor expression
Author(s) -
Simone C.,
Guerriero C.,
Venier A.,
Rumi C.,
Bussa S.,
Fresu R.,
Sole P.
Publication year - 1993
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1993.tb00014.x
Subject(s) - chemiluminescence , opsonin , zymosan , chemistry , immunology , psoriasis , receptor , flow cytometry , u937 cell , antibody , medicine , biochemistry , chromatography , in vitro
The role of the two main serum opsonins (IgG and C3b) in the induction of polymorphonuclear leukocyte chemiluminescence was studied in a group of psoriatic patients. Chemiluminescence was stimulated with zymosan opsonized by fresh plasma (IgG‐ and C 3 b‐dependent chemiluminescence) or by complement‐depleted plasma (IgG‐dependent chemiluminescence). While C 3 b‐dependent chemiluminescence was similar in patients with chronic or active forms of psoriasis. IgG‐dependent chemilumi‐nescence was significantly increased in patients with active disease. However, FcR‐III expression, evaluated by means of flow cytofluorimetry. was similar in the different groups of patients studied. The discrepancy between Fc‐receptor (CD 16) expression and IgG‐dependent chemilumi‐nescence is, therefore, indicative of modifications that occur in psoriatic neutrophils that do not involve FcIII‐receptor expression.