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Studies and perspectives of signal transduction in the skin
Author(s) -
Inohara Shinichi
Publication year - 1992
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.1992.tb00079.x
Subject(s) - protein kinase c , signal transduction , phorbol ester , microbiology and biotechnology , tyrosine kinase , kinase , transduction (biophysics) , epidermal growth factor , biology , chemistry , biochemistry , receptor
Tumor‐promoting phorbol ester and epidermal growth factor (EGF) exert marked influences on the proliferation and differentiation of keratinocytes. These two agents bring their physiological functions into play via protein kinase C (PKC) activation (and/or down regulation) and protein tyrosine kinase, respectively. In this paper, the present situation in the studies on the signal transduction of keratinocytes centering around these two kinases is discussed. An outline of studies on signal transduction of cells other than keratinocytes in the skin is also given.