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Comparable outcomes between unrelated and related donors after reduced‐intensity conditioning allogeneic hematopoietic stem cell transplantation in patients with high‐risk multiple myeloma
Author(s) -
ElCheikh Jean,
Crocchiolo Roberto,
Boher JeanMarie,
Furst Sabine,
Stoppa AnneMarie,
Ladaique Patrick,
Faucher Catherine,
Calmels Boris,
Castagna Luca,
Lemarie Claude,
De Colella JeanMarc Schiano,
Coso Diane,
Bouabdallah Reda,
Chaban Christian,
Blaise Didier
Publication year - 2012
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2012.01777.x
Subject(s) - multiple myeloma , hematopoietic stem cell transplantation , medicine , stem cell , transplantation , conditioning , hematopoietic cell , oncology , haematopoiesis , immunology , biology , genetics , statistics , mathematics
The purpose of this study was to assess the results of allogeneic stem cell transplantation (allo‐SCT) after reduced‐intensity conditioning (RIC) from matched related donors (MRD) and unrelated donors (URD) in 40 patients with high‐risk multiple myeloma (MM) in a single centre. Seventeen (43%) (Group 1) and 23 patients (57%) (Group 2) had URD and MRD, respectively. Thirty‐nine patients (98%) received one or more autologous transplantation. The median follow‐up was 22 months (1–49). None of our patient experienced a graft rejection. The cumulative incidence of grade II–IV acute GVHD was higher (47%) for the URD vs. (17%) for the MRD ( P = 0.092). The cumulative incidence of chronic GVHD was no different between the two groups (24% vs. 30%, respectively). At 2 yr, the TRM probabilities were lower in the unrelated group 12% vs. 22% in the related group ( P = 0.4). Also at 2 yrs, for patients receiving unrelated transplantation overall and progression‐free survivals, 59% and 42%, respectively compared to patients with related donor transplantation, 66% and 44% ( P = 0.241). In conclusion, these results suggest that URD in MM is feasible. The small number of patients with URD emphasizes the need to delineate indications and perform prospective protocols.