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Are T‐cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes?
Author(s) -
Fozza Claudio,
Longinotti Maurizio
Publication year - 2012
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2012.01762.x
Subject(s) - myelodysplastic syndromes , pathogenesis , immunology , disease , immune system , transplantation , haematopoiesis , biology , medicine , stem cell , pathology , bone marrow , genetics , surgery
Even though the pathogenesis of myelodysplastic syndromes (MDS) is dominated by an inefficient maturation of haematopoietic precursors, also immune mechanisms seem to play a crucial functional role. In this review, we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus on studies addressing the mechanisms of T‐cell activation and their implications in the disease history. The potential impact of specific cell subsets, such as regulatory T‐cells, Th17 cells and natural killer cells, will be also described. We will finally focus on potential therapeutic approaches based on immunomodulation, ranging from more classical immunosuppressive drugs to vaccination and transplantation strategies.