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Non‐myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia
Author(s) -
Cervera Carlos,
FernándezAvilés Francesc,
de la CalleMartin Oscar,
Bosch Xavier,
Rovira Montserrat,
Plana Montse,
Moreno Asunción,
García Felipe,
Miró Jose M.,
Martínez Antonio,
Gallart Teresa,
Carreras Enric,
Blade Joan,
Gatell Jose M.
Publication year - 2011
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2011.01619.x
Subject(s) - lymphocytopenia , medicine , leukapheresis , hematopoietic stem cell transplantation , fludarabine , total body irradiation , stem cell , transplantation , myeloid , immunology , haematopoiesis , gastroenterology , cd34 , surgery , lymphocyte , chemotherapy , cyclophosphamide , biology , genetics
Abstract A 40‐year‐old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non‐myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total‐body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA‐identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow‐up period. The patient did not develop infectious complications during the procedure. At 35 months of follow‐up, his CD4+ T cell count was 1019 cells per microliter. Non‐myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.