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Emerging therapies for the treatment of relapsed or refractory multiple myeloma
Author(s) -
Dimopoulos Meletios A.,
SanMiguel Jesus F.,
Anderson Kenneth C.
Publication year - 2011
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2010.01542.x
Subject(s) - multiple myeloma , medicine , refractory (planetary science) , clinical trial , histone deacetylase , bortezomib , proteasome inhibitor , oncology , lenalidomide , cancer research , bioinformatics , histone , biology , biochemistry , astrobiology , gene
Encouraging progress has been made in the treatment of patients with relapsed/refractory multiple myeloma (MM). The rapidly evolving understanding of key pathways responsible for tumor growth and survival has led to the development of novel agents (including immunomodulatory drugs, proteasome inhibitors, histone deacetylase inhibitors, and other targeted agents) with the potential to provide significant improvements in response and survival, and influence treatment guidelines. This review summarizes recent advances in understanding of the biology of relapsed/refractory MM and clinical trials with novel targeted agents that are currently under investigation for patients with this disease.