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What changes in health‐related quality of life matter to multiple myeloma patients? A prospective study *
Author(s) -
Kvam Ann K.,
Fayers Peter,
Wisloff Finn
Publication year - 2010
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2009.01404.x
Subject(s) - quality of life (healthcare) , receiver operating characteristic , medicine , multiple myeloma , minimal clinically important difference , prospective cohort study , cancer , randomized controlled trial , nursing
Objective: To determine the clinical significance of changes in quality‐of‐life scores in patients with multiple myeloma (MM), we have estimated the minimal important difference (MID) for the health‐related quality‐of‐life instrument, the European Organization for Research and Treatment of Cancer (EORTC) QLQ‐C30. The MID is the smallest change in a quality‐of‐life score considered important to patients. Methods: Between 2006 and 2008, 239 patients with MM completed the EORTC QLQ‐C30 at inclusion (T1) and after 3 months (T2). At T2, a structured quality‐of‐life interview was also performed. MIDs were calculated by using mean score changes (T2–T1) for patients who in the interview stated they had improved, deteriorated or were unchanged. MIDs were also estimated by the receiver‐operating characteristic (ROC) curve method as well as by calculation effect sizes using standard deviations of baseline scores. Results: MIDs varied slightly depending on the method used. Patients stating in the interview that they had ‘improved’ or ‘deteriorated’ had a corresponding change in EORTC QLQ‐C30 score ranging from 6 to15 (improvement) and from 9 to17 (deterioration) (scale range 0–100). The ROC analysis indicated that changes in score from 7 to17 represent clinically important changes to patients. The effect size method suggested 5–6 to be a small and 11–15 to be a medium change. Conclusion: Calculation of MIDs as mean score changes or by ROC analysis suggested that a change in the EORTC QLQ‐C30 score in the range of approximately 6–17 is considered important by patients with MM. These MIDs are closer to a medium effect size than to a small effect size. Our findings imply that mean score changes smaller than 6 are unlikely to be important to the patients, even if these changes are statistically significant.