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Acute megakaryoblastic leukemia in a child with the MLL‐AF4 fusion gene
Author(s) -
Takita Junko,
Motomura Ai,
Koh Katsuyoshi,
Ida Kohmei,
Taki Tomohiko,
Hayashi Yasuhide,
Igarashi Takashi
Publication year - 2009
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2009.01275.x
Subject(s) - acute megakaryoblastic leukemia , myeloid leukemia , leukemia , fusion gene , lineage (genetic) , down syndrome , acute leukemia , myeloid , medicine , chromosomal translocation , cancer research , gene , biology , immunology , genetics
Mixed‐lineage leukemia ( MLL ) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy‐related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL‐AF4 fusion transcript. MLL‐AF4 is derived from t(4;11)(q21:q23) and occurs exclusively in B‐cell lineage leukemia. To our knowledge, MLL‐AF4 as well as t(4;11)(q21:q23) has not been reported in adult and childhood AMKL. Thus, our case provides new insight into the molecular mechanisms of MLL‐AF4 ‐associated leukemia.