Premium
Acute splenic complications and implications of splenectomy in hemoglobin SC disease
Author(s) -
Subbannan Karthi,
Ustun Celalettin,
Natarajan Kavita,
Clair Betsy,
Daitch Lisa,
Fields Sabine,
Kutlar Ferdane,
Kutlar Abdullah
Publication year - 2009
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2009.01270.x
Subject(s) - splenectomy , medicine , gastroenterology , spleen , cholecystectomy , platelet , surgery , mortality rate , adverse effect
Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non‐splenectomy group, respectively, regarding Hb levels (median 7.2 g/dL vs. 12.5 g/dL, P < 0.0001), platelet counts (median 146 × 10 6 /L vs. 275 × 10 6 /L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12% P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short‐term complications of surgery, long‐term adverse effects such as infections have to be evaluated cautiously.