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A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
Author(s) -
Nakamura Yuichi,
Sato Yasutaka,
Yoshida Katsuhiko,
Kakegawa Emi,
Ito Yoshihiro,
Seyama Atsushi,
Kayano Hidekazu,
Bessho Masami
Publication year - 2009
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2009.01233.x
Subject(s) - follicular lymphoma , biology , bone marrow , clone (java method) , immunoglobulin heavy chain , lymph node , immunoglobulin light chain , lymphoma , gene rearrangement , germline , antibody , microbiology and biotechnology , gene , cancer research , genetics , immunology
We report a follicular lymphoma (FL) case presenting the coexistence of two tumor cell subpopulations in lymph node (LN) and bone marrow (BM), which exhibited an inverse pattern of immunoglobulin light (IgL) chain gene rearrangement and expression: Igκ−λ+ in LN and Igκ+λ− in BM. These tumor clones shared an identical BCL2‐IgH recombination, accompanying t(14;18)(q32;q21) translocation, and an identical variable, diversity and joining segments joining with clone‐specific VH somatic hypermutations on the untranslocated IgH allele. Our study provides further evidence that FL clones, originating from common progenitor cells, can be developed independently at different sites and with different IgL expression after immune selection.