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Detection of the STAT5B–RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G‐banding
Author(s) -
Kusakabe Manabu,
Suzukawa Kazumi,
Nanmoku Toru,
Obara Naoshi,
Okoshi Yasushi,
Mukai Harumi Y.,
Hasegawa Yuichi,
Kojima Hiroshi,
Kawakami Yasushi,
Ninomiya Haruhiko,
Nagasawa Toshiro
Publication year - 2008
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2008.01042.x
Subject(s) - acute promyelocytic leukemia , retinoic acid , biology , chromosomal translocation , fusion gene , chromosomal rearrangement , cancer research , fusion transcript , chromosome 15 , leukemia , microbiology and biotechnology , gene , bone marrow , chromosome , genetics , karyotype , immunology
Acute promyelocytic leukemia (APL) is characterized by chromosomal rearrangements of 17q21, leading to fusion of the gene‐encoding retinoic acid receptor alpha ( RARA ) with a number of alternative partner genes. Signal transducer and activator of transcription 5 beta ( STAT5B ) is one of the alternative partners. We report a rare case of APL with STAT5B–RARA fusion transcript and the normal chromosome 17 on G‐banding. Administration of all trans ‐retinoic acid improved disseminated intravascular coagulation without decrease of the leukemia cells in his peripheral blood and bone marrow. The molecular mechanism of fusion between STAT5B and RARA by chromosomal rearrangement is discussed based on the data from genome database. Clinical characteristics of APL with STAT5B–RARA are also discussed.