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Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2 V617F allele burden correlates
Author(s) -
Gangat Naseema,
Strand Jacob,
Lasho Terra L.,
Finke Christy M.,
Knudson Ryan A.,
Pardanani Animesh,
Li ChinYang,
Ketterling Rhett P.,
Tefferi Ayalew
Publication year - 2008
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2007.01003.x
Subject(s) - polycythemia vera , jak2 v617f , medicine , allele , gastroenterology , genetics , myelofibrosis , biology , gene , bone marrow
The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a −Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 ( n = 4), trisomy 9 ( n = 2), deletion 20q ( n = 2) and chromosomal 1 abnormalities ( n = 2). Parameters that were significantly associated with abnormal cytogenetics included age ≥60 yr ( P = 0.02), but not JAK2 V617F allele burden, thrombosis, hemorrhage, leukemic/fibrotic transformation, or survival. We conclude that cytogenetic anomalies occur infrequently at PV diagnosis and do not confer an adverse outcome.