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Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B‐ and T‐cell markers
Author(s) -
Hansson Markus,
Jerkeman Mats,
Dictor Michael
Publication year - 2007
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2007.00882.x
Subject(s) - pax5 , biology , lymphoma , antigen , gene , b cell , cd30 , bcl10 , genotype , cell , microbiology and biotechnology , cancer research , transcription factor , immunology , antibody , genetics
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B‐ and T‐cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B‐ and T‐cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42‐yr‐old female with a peripheral CD30 + lymphoma that displayed both characteristic B‐ and T‐cell surface antigens and clonal rearrangement of B‐ and T‐cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B‐cell differentiation did not preclude expression of CD3ε, generally assumed to be a T‐cell associated antigen.