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Telomere length and correlation with histopathogenesis in B‐cell leukemias/lymphomas
Author(s) -
Walsh Sarah H.,
Grabowski Pawel,
Berglund Mattias,
Thunberg Ulf,
Thorsélius Mia,
Tobin Gerard,
Åleskog Anna,
Karlsson Karin,
Sundström Christer,
Laurell Anna,
Enblad Gunilla,
Rosenquist Richard,
Roos Göran
Publication year - 2007
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2007.00817.x
Subject(s) - telomere , biology , germinal center , chronic lymphocytic leukemia , lymphoma , b cell , mantle cell lymphoma , diffuse large b cell lymphoma , cancer research , leukemia , gene , microbiology and biotechnology , antibody , immunology , genetics
Telomere length was recently reported to correlate with cellular origin of B‐cell malignancies in relation to the germinal center (GC). In this report, we measured telomere length by quantitative‐PCR in 223 B‐cell lymphomas/leukemias and correlated results with immunoglobulin (Ig) mutation status and immunostainings for GC/non‐GC subtypes of diffuse large B‐cell lymphoma (DLBCL). Shortest telomeres were found in Ig‐unmutated chronic lymphocytic leukemia (CLL) [median telomere to single copy gene value (T/S) 0.33], differing significantly to Ig‐mutated CLL (0.63). Contrary to this, mantle cell lymphomas (MCLs) exhibited similar telomere lengths regardless of Ig mutation status (0.47). Telomere length differed significantly between GC‐like (0.73) and non‐GC‐like DLBCLs (0.43), and follicular lymphomas (FLs) had shorter telomeres (0.53) than GC‐DLBCL. Hairy cell leukemias, which display Ig gene intraclonal heterogeneity, had longer telomeres (0.62) than FLs and non‐GC‐DLBCL, but shorter than GC‐DLBCL. We conclude that although DLBCL and CLL subsets can be clearly distinguished, telomere length reflects many parameters and may not simply correlate with GC‐related origin.