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Herpes simplex and Epstein‐Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine
Author(s) -
Mercadal Santiago,
Martinez Antonio,
Nomdedeu Benet,
Rozman María,
Gaya Anna,
Salamero Olga,
Campo Elías
Publication year - 2006
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2006.00738.x
Subject(s) - chronic lymphocytic leukemia , coinfection , fludarabine , herpes simplex virus , medicine , virus , virology , epstein–barr virus , immunology , herpesviridae , leukemia , complication , viral disease , chemotherapy , cyclophosphamide
Multiple herpes virus co‐infection is a very rare complication in patients with chronic lymphocytic leukemia (CLL). We describe a patient with a CLL who developed an herpes virus lymphadenitis. Inmunohistochemical study was positive for HSV‐1, HSV‐2, and Epstein‐Barr Virus (EBV). The coinfection of EBV with a profile of expresion of viral latent genes type III, is usually seen in inmunodepressed patients. To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome.