Herpes simplex and Epstein‐Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine | Zendy

Mercadal Santiago | Zendy; Martinez Antonio | Zendy; Nomdedeu Benet | Zendy; Rozman María | Zendy; Gaya Anna | Zendy; Salamero Olga | Zendy; Campo Elías | Zendy

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Herpes simplex and Epstein‐Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine

Author(s) -

Mercadal Santiago,

Martinez Antonio,

Nomdedeu Benet,

Rozman María,

Gaya Anna,

Salamero Olga,

Campo Elías

Publication year - 2006

Publication title -

european journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 84

eISSN - 1600-0609

pISSN - 0902-4441

DOI - 10.1111/j.1600-0609.2006.00738.x

Subject(s) - chronic lymphocytic leukemia , coinfection , fludarabine , herpes simplex virus , medicine , virus , virology , epstein–barr virus , immunology , herpesviridae , leukemia , complication , viral disease , chemotherapy , cyclophosphamide

Multiple herpes virus co‐infection is a very rare complication in patients with chronic lymphocytic leukemia (CLL). We describe a patient with a CLL who developed an herpes virus lymphadenitis. Inmunohistochemical study was positive for HSV‐1, HSV‐2, and Epstein‐Barr Virus (EBV). The coinfection of EBV with a profile of expresion of viral latent genes type III, is usually seen in inmunodepressed patients. To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome.

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