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Hydrops lysosomalis generalisatus – an underestimated side effect of hydroxyethyl starch therapy?
Author(s) -
SchmidtHieber Martin,
Loddenkemper Christoph,
Schwartz Stefan,
Arntz Gesine,
Thiel Eckhard,
Notter Michael
Publication year - 2006
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2006.00657.x
Subject(s) - hydroxyethyl starch , bone marrow , medicine , liver biopsy , pathology , liver dysfunction , biopsy , infiltration (hvac) , differential diagnosis , gastroenterology , physics , thermodynamics
Hydroxyethyl starch (HES) is usually considered to be associated with limited side effects. Generalized foamy cell macrophage syndrome after HES therapy has rarely been reported since Schaefer first described it as ‘hydrops lysosomalis generalisatus’ in 1982. We present a 19‐yr‐old male who received large amounts of HES. A bone marrow and a liver biopsy were performed because of persistent thrombocytopenia and liver dysfunction. We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction.