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Transplantation of umbilical cord blood‐derived endothelial progenitor cells: a promising method of therapeutic revascularisation
Author(s) -
Zhang Lei,
Yang Renchi,
Han Zhong Chao
Publication year - 2006
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2005.00579.x
Subject(s) - progenitor cell , medicine , umbilical cord , transplantation , therapeutic effect , stem cell , regeneration (biology) , umbilical cord blood transplantation , therapeutic approach , therapeutic angiogenesis , surgery , immunology , neovascularization , cancer research , pathology , angiogenesis , hematopoietic stem cell transplantation , biology , microbiology and biotechnology , disease
Therapeutic neovascularisation by endothelial progenitor cells (EPCs) mediated vascular regeneration is becoming a novel option for the treatment of ischaemic diseases. Recently, human umbilical cord blood (CB) has been found to contain a large number of EPCs and transplantation of CB EPCs led to a successful salvage of the ischaemic limbs through improvement in blood perfusion, indicating the feasibility of using CB cells for therapeutic revascularisation. This review will summarise recent studies in therapeutic revascularisation using CB cells and discuss the potential clinical utilisation of CB cells in ischaemic diseases.