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Cardiac presentation of ALK positive anaplastic large cell lymphoma
Author(s) -
Lim Z. Y.,
Grace R.,
Salisbury J. R.,
Creamer D.,
Jayaprakasam A.,
Ho A. Y. L.,
Devereux S.,
Mufti G. J.,
Pagliuca A.
Publication year - 2005
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2005.00542.x
Subject(s) - medicine , anaplastic large cell lymphoma , lymphoma , biopsy , presentation (obstetrics) , anaplastic lymphoma kinase , cd30 , large cell , differential diagnosis , large cell lymphoma , radiology , pathology , cancer , adenocarcinoma , malignant pleural effusion , pleural effusion
  Cardiac involvement as an initial presentation of malignant lymphoma is a rare occurrence. We report the case of an immunocompetent 29‐year‐old male who presented with syncope and arrythmias secondary to a ventricular cardiac mass. Transcutaneous cardiac biopsy was non‐diagnostic, therefore an open cardiac biopsy was performed from which a provisional diagnosis of a cardiac inflammatory pseudotumour was made. Six months after presentation, he developed several subcutaneous lesions with systemic symptoms. Histological and immunophenotypic review of the initial cardiac biopsy revealed features consistent with a diagnosis of CD30, ALK1 positive anaplastic large cell lymphoma (ALCL). Despite intensive treatment with combination chemotherapy, there was significant progression of disease, and he died 11 months after diagnosis. The overall prognosis of cardiac lymphoma remains poor, which may be due to the often late presentation of the tumour. To our knowledge, this is the first reported case of a cardiac ALK positive ALCL. Although rare, cardiac presentation of ALCL should be added to the list of differential diagnoses of cardiac lymphomas.

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