Premium
Report: workshop on mediastinal grey zone lymphoma
Author(s) -
Poppema Sibrand,
Kluiver Joost L,
Atayar Cigdem,
Berg Anke,
Rosenwald Andreas,
Hummel Michael,
Lenze Dido,
Lammert Hetty,
Stein Harald,
Joos Stephan,
Barth Thomas,
Dyer Martin,
Lichter Peter,
Klein Uwe,
Cattoretti Giorgio,
Gloghini Annunziata,
Tu Yuhai,
Stolovitzky Gustavo A,
Califano Andrea,
Carbone Antonino,
DallaFavera Ricardo,
Melzner Ingo,
Bucur Alexandra J,
Brüderlein Silke,
Dorsch Karola,
Hasel Cornelia,
Barth Thomas FE,
Leithäuser Frank,
Möller Peter
Publication year - 2005
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2005.00454.x
Subject(s) - lymphoma , germinal center , biology , bcl10 , anaplastic lymphoma kinase , pathology , chemokine , cancer research , b cell , oncogene , gene rearrangement , gene , antibody , receptor , immunology , medicine , lung cancer , genetics , cell cycle , malignant pleural effusion
There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms. The first indication was the existence of mediastinal grey zone lymphomas as identified in the 4th International Symposium on HL, with clinical, histological and immunohistochemical features intermediate between cHL and PMBL. Second, both tumor types resemble a cell that is developmentally situated in‐between the germinal center reaction and a plasma cell. Third, cHL and PMBL were found to have similar gene expression profiles, including the lack of immunoglobulin expression and low levels of B cell receptor signalling molecules, and the secretion of molecules like the chemokine TARC and the prominent expression of IL‐13 receptors. Fourth, both entities were found to have common genomic aberrancies, notably in 2p15 and 9p24, the sites of the REL oncogene and the tyrosine kinase gene JAK2, respectively. Further comparison of both lymphoma types may provide further insight in the pathogenic mechanisms and allow the design of diagnostic algorithms to sort out the small number of so‐called mediastinal grey zone lymphomas, that appear to be intermediate between PMBL and cHL.