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Successful non‐T‐cell‐depleted HLA‐haploidentical 3‐loci mismatched bone marrow transplantation
Author(s) -
Yagyu Shigeki,
Kuroda Hiroshi,
Fujiki Atsushi,
Tamura Shinichi,
Iehara Tomoko,
Morimoto Akira,
Hosoi Hajime,
Sugimoto Tohru,
Imashuku Shinsaku
Publication year - 2005
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2005.00430.x
Subject(s) - bone marrow transplantation , human leukocyte antigen , transplantation , immunology , bone marrow , medicine , histocompatibility testing , biology , antigen
A 17‐year‐old boy with therapy‐related acute myelocytic leukemia (FAB classification‐M0) successfully received allogeneic non‐T‐cell depleted (non‐TCD) bone marrow transplantation (BMT) from his 3‐loci HLA‐mismatch mother, although pre‐BMT detection of feto‐maternal microchimerism was negative. The BMT was performed with reduced intensity conditioning (total body irradiation; 4 Gy, fludarabine; 20 mg/m 2 × 6, and melphalan; 70 mg/m 2 × 2) and short‐course methotrexate and tacrolimus for GVHD prophylaxis. Complete donor chimera was obtained on day 19, associated with Grade 3 acute GVHD (skin: Stage 1, liver: Stage 0, gut: Stage 3) that was well controlled with immunosuppressive therapies. At day 200 of transplantation, he was in complete remission with no signs of chronic GVHD. Our case suggests that non‐TCD HLA‐haploidentical 3‐loci mismatched BMT can be safely performed from mother to offspring even when feto‐maternal microchimerism is barely detectable with the current detection procedure.