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Autografting followed by a reduced‐intensity conditioning unrelated donor cord blood transplantation for a patient with refractory multiple myeloma: successful engraftment with minimal toxicity
Author(s) -
Ando Toshihiko,
Yujiri Toshiaki,
Tominaga Takayuki,
Shinya Sonoe,
Takahashi Toru,
Nomiyama Jun,
Seguchi Masato,
Matsubara Atsushi,
Fujii Yasuhiko,
Tanizawa Yukio
Publication year - 2005
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2004.00364.x
Subject(s) - medicine , multiple myeloma , chemotherapy , umbilical cord , transplantation , refractory (planetary science) , surgery , umbilical cord blood transplantation , autologous stem cell transplantation , oncology , urology , hematopoietic stem cell transplantation , immunology , physics , astrobiology
We report on a 59‐yr‐old man with recurrent multiple myeloma. To reduce treatment‐related mortality, while retaining the cytoreductive effects of high‐dose chemotherapy, as well as graft vs. myeloma effect, we used a reduced‐intensity conditioning umbilical cord blood (CB) transplantation following high‐dose chemotherapy with autologous stem cell transplantation support. This patient was engrafted rapidly and extramedullary toxicities were acceptable. Although he had local recurrence in the right calf on day +130 after the CB transplantation, the tumor was successfully treated with radiation therapy, and he is alive and well at present (day +480).