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Zoledronate‐induced remission of acute panmyelosis with myelofibrosis
Author(s) -
Español I.,
Romagosa V.,
Berlanga J.,
Domingo A.,
Losa F.,
Heras L.,
Janáriz J.
Publication year - 2004
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.2004.00277.x
Subject(s) - pancytopenia , myelofibrosis , medicine , infiltration (hvac) , myeloid leukemia , bone marrow , osteosclerosis , biopsy , acute leukemia , bisphosphonate , myeloid , pathology , leukemia , osteoporosis , physics , thermodynamics
Acute panmyelosis with myelofibrosis is a rare and aggressive form of acute myeloid leukemia. We describe a new case with a huge proliferation of megakaryocytes, blast cells and reticulin fibers. The patient was treated with zoledronate, a third‐generation bisphosphonate, and a gradual recovery from pancytopenia was observed. A new bone marrow biopsy performed 4 months later showed a surprising disappearance of the leukemic infiltration. Ten months after the diagnosis, the patient is still in healthy condition. This may support the recently described anti‐tumor activity of zoledronate.