Premium
Pathogenetic factors underlying juvenile deep vein thrombosis (DVT) in Indians
Author(s) -
Saxena Renu,
Mohanty Sujata,
Srivastava Anurag,
Choudhry Ved Prakash,
Kotwal Jyoti
Publication year - 1999
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1999.tb01846.x
Subject(s) - medicine , protein c , lupus anticoagulant , deep vein , thrombosis , protein s , activated protein c resistance , antithrombotic , antithrombin , gastroenterology , protein c deficiency , factor v , venous thrombosis , endocrinology , factor v leiden , heparin
The role of hereditary antithrombotic protein defects in juvenile deep vein thrombosis (DVT) was evaluated. Fifty six young patients (age <45 yr) with doppler‐proven DVT were investigated for the presence of resistance to activated protein C (APC‐R), lupus anticoagulant (LA), anticardiolipin antibodies and deficiencies of protein C, protein S, ATIII activities. Fifty nine normal healthy individuals served as controls. APC‐R was observed to be the commonest defect underlying the Indian DVT as seen in 39.2% of patients followed by elevated ACA (5.3%), PAI (2.8%), presence of LA (2.8%) and reduced ATIII levels (2.8%). None of the subjects had protein C or S deficiency. APC‐R was associated with ATIII deficiency in one case, and elevated ACA in two cases. In two subjects, APC‐R was associated with elevated PAI levels. Patients with more than one prothrombotic factor had a higher prevalence of pulmonary thromboembolism, suggesting that the thrombogenic potential of APC‐R is enhanced by the presence of coexisting hereditary or acquired prothrombotic defect.