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In vitro effects of insulin‐like growth factor‐1 (IGF‐1) on proliferation and constitutive cytokine secretion by acute myelogenous leukemia blasts
Author(s) -
Frostad S.,
Bruserud Ø.
Publication year - 1999
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1999.tb01743.x
Subject(s) - cytokine , insulin like growth factor , growth factor , cancer research , leukemia , secretion , in vitro , medicine , immunology , endocrinology , biology , receptor , genetics
The effects of insulin‐like growth factor 1 (IGF‐1) on autonomous proliferation, cytokine‐dependent proliferation and constitutive cytokine secretion by acute myelogenous leukemia (AML) blasts were investigated using serum‐free in vitro conditions. IGF‐1 enhanced AML blast proliferation independent of the presence of other exogenous cytokines only for 2 of 21 patients, but for 10 additional patients IGF‐1 altered blast proliferation in the presence of certain exogenous cytokines or cytokine combinations. IGF‐1 had minor effects on AML blast cytokine secretion only for a subset of the patients (decreased levels for 1 patient, increased levels for 7 patients). Our in vitro observations indicate that IGF‐1 can modulate AML blast proliferation and/or cytokine secretion for a subset of patients.