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Prognostic implications of cytogenetic aberrations in diffuse large B‐cell lymphomas
Author(s) -
Jerkeman M.,
Johansson B.,
Åkerman M.,
CavallinStåhl E.,
Kristoffersson U.,
Mitelman F.
Publication year - 1999
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1999.tb01742.x
Subject(s) - trisomy , breakpoint , monosomy , biology , cytogenetics , dup , univariate analysis , pathology , aneuploidy , karyotype , medicine , oncology , chromosome , genetics , gene duplication , multivariate analysis , gene
A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B‐cell lymphomas (DLBL), the majority of which treated with anthracycline‐containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21–23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21–25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11–12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, >4 marker chromosomes, >4 breakpoints, and ≥10 abnormalities. Univariate analysis showed that a breakpoint at 1q21–23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above‐mentioned abnormalities being of prognostic importance in DLBL.