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Low‐dose oral iron absorption test in anaemic patients with and without iron deficiency determined by bone marrow iron content
Author(s) -
Jensen Nanna M.,
Brandsborg Margrethe,
Boesen Anne M.,
Yde Hans,
Dahlerup Jens F.
Publication year - 1999
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1999.tb01123.x
Subject(s) - bone marrow , iron deficiency , anemia , iron isotopes , medicine , gastroenterology , iron deficiency anemia , absorption (acoustics) , materials science , isotope , physics , quantum mechanics , composite material
The low‐dose oral iron absorption test (OIAT) was performed in 85 consecutive anaemic patients referred for bone marrow examination in order to investigate the ability of the test to predict bone marrow iron stores and to differentiate between different categories of anaemia. Eight patients were excluded for technical reasons. Test results from 77 patients are presented as C max (μmol/l): the maximum increase in S‐iron measured during a 3 h period after administration of 10 mg oral iron sulfate. Iron deficiency was defined as the absence of stainable iron in bone marrow aspirates. C max was higher in 46 iron deficient patients [3 (median); 0 and 13 (1st and 3rd quartiles); 0–40 (range)] than in 31 non‐iron‐deficient patients (0; 0 and 2; 0–4) ( p <0.01). 27 patients had primary bone marrow disease, 25 patients had absent bone marrow iron stores accompanied by inflammation, 17 patients had anaemia of chronic disease (ACD) and 8 patients had uncomplicated iron deficiency anaemia (IDA). Patients with IDA had higher C max (15; 13 and 28; 6–40) than patients with ACD (1; 0 and 2; 0–3), and than the 69 non‐IDA patients (1; 0 and 3; 0–19) ( p <0.001). C max values above 5 μmol/l always indicated absent bone marrow iron stores.