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A staging system for multiple myeloma based on the morphology of myeloma cells
Author(s) -
Murakami Hirokazu,
Kawada Tomoyuki,
Saitoh Takayuki,
Uchiumi Hideki,
Moridaira Kazuaki,
Matsushima Takafumi,
Tsukamoto Norifumi,
Tamura Jun'ichi,
Morita Kimio,
Sawamura Morio,
Karasawa Masamitsu,
Miyawaki Shuichi,
Shiome Shogo,
Shimano Shunichi,
Sato Sadao,
Ogawara Hatsue,
Tsuchiya Jun
Publication year - 1999
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1999.tb01116.x
Subject(s) - multiple myeloma , morphology (biology) , staging system , medicine , pathology , biology , cancer , genetics
The morphology of myeloma cells is reported to be one of the prognostic factors in multiple myeloma (MM) patients. We analyzed the prognostic factors, including morphological classification, in 292 patients with MM in order to select poor‐risk patients who should be considered candidates for early intensive chemotherapy, including stem cell transplantation. Multivariate analysis was applied to 90 patients diagnosed between 1989 and 1996, because serum beta‐2‐microglobulin (β 2 M) has been measured regularly since 1989, and showed that serum albumin, serum β 2 M, and the morphology of myeloma cells predicted survival. According to these factors, patients were divided into 3 risk groups; a high‐risk group (14%), a intermediate‐risk group (46%) and a low‐risk group (40%). There were significant differences between survival times in these 3 groups (median survival: high‐risk, 16; intermediate‐risk, 22; and low‐risk, 44 months).