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Impact of endogenous thrombopoietin levels on the differential diagnosis of essential thrombocythaemia and reactive thrombocytosis
Author(s) -
Hou Ming,
Carneskog Jan,
Mellqvist UlfHenrik,
Stockelberg Dick,
Hedberg Martin,
Wadenvik Hans,
Kutti Jack
Publication year - 1998
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1998.tb01071.x
Subject(s) - thrombocytosis , thrombopoietin , medicine , differential diagnosis , endogeny , platelet , immunology , pathology , biology , haematopoiesis , stem cell , genetics
By using the newly commercialized Quantikine TM human TPO immunoassay, plasma thrombopoietin (TPO) concentrations were measured in 12 patients with essential thrombocythaemia (ET), 13 patients with reactive thrombocytosis (RT) and 11 healthy volunteers. For the healthy volunteers the mean plasma TPO concentration was 21.1±11.0 pg/ml. The mean plasma TPO concentration in the group of RT was slightly lower (16.4±8.6 pg/ml) but did not differ significantly from the control group. The mean plasma TPO concentration in ET patients (44.1 ±45.2 pg/ml) was significantly ( p <0.05) higher than the mean for RT patients, but did not differ statistically from the mean of healthy volunteers. These data suggest a defective clearance of plasma TPO in patients with ET.