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How does interferon exert its cell growth inhibitory effect?
Author(s) -
Grandér Dan,
Sangfelt Olle,
Erickson Sven
Publication year - 1997
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1997.tb00965.x
Subject(s) - inhibitory postsynaptic potential , mechanism of action , interferon , mechanism (biology) , perspective (graphical) , cell growth , biology , cancer research , action (physics) , cell , immunology , neuroscience , genetics , in vitro , computer science , philosophy , physics , epistemology , quantum mechanics , artificial intelligence
The interferons (IFNs) have become accepted therapy in a range of haematological and non‐haematological malignancies. The mechanism behind IFN's antitumour action is, however, unclear. Interferons (IFNs) are capable of modulating a variety of cellular responses. One prominent effect of IFNs is their cell growth inhibitory activity, which has also been suggested to be of major importance in their antitumour action. In the present review we will discuss the cellular events leading to a decreased number of cells following IFN treatment, the molecular mechanisms underlying these phenomena, and the importance of these effects in a clinical perspective.