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Characterization and regulation of interleukin‐4 receptor in adult T‐cell leukemia cells
Author(s) -
Mori Naoki,
Shirakawa Fumihiko,
Murakami Shuichi,
Oda Susumu,
Eto Sumiya
Publication year - 1996
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1996.tb01936.x
Subject(s) - t cell leukemia , leukemia , biology , flow cytometry , receptor , receptor expression , interleukin 9 , interleukin 2 , cell , immunology , interleukin 3 , t cell , interleukin , microbiology and biotechnology , cancer research , cytokine , interleukin 21 , immune system , biochemistry , genetics
We studied the expression of the receptor of interleukin (IL)‐4, one of the T cell growth factors, on fresh peripheral blood leukemic cells from adult T‐cell leukemia (ATL) patients. Flow cytofluorometric analysis with a monoclonal antibody to the IL‐4 receptor (IL‐4R) were used to investigate whether expression of IL‐4R on ATL cells is different from that on normal lymphocytes and other types of leukemic cells. Leukemic cells from acute type ATL patients synthesize IL‐4R without stimulation, at levels much higher than normal resting lymphocytes and other types of leukemic cells. Furthermore, leukemic cells from acute type ATL showed higher IL‐4R expression than that of chronic type ATL or human T‐cell leukemia virus type I carriers. In addition, there was correlation between expression of IL‐4R on the cell surface and the proliferative response to IL‐4. Both IL‐4 and IL‐2 induced upregulation of IL‐4R on activated normal T cells but not on ATL cells. These results suggest that abnormal expression of IL‐4R may display different biological activities in ATL compared with other types of leukemia. Furthermore, the high expression of IL‐4R in ATL may be involved in the proliferation of leukemic cells and the leukemogenesis in this disease.