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The effect of desmopressin on platelet aggregation defect in systemic amyloidosis: a preliminary report
Author(s) -
Demiroǧlu Haluk,
Barişta Ibrahim,
Gürsoy Murat,
Oymak Oktay,
Diindar Semra
Publication year - 1996
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1996.tb00716.x
Subject(s) - hyperfibrinolysis , medicine , desmopressin , amyloidosis , platelet , bleeding diathesis , al amyloidosis , epinephrine , coagulopathy , platelet activating factor , hemostasis , gastroenterology , immunology , antibody , immunoglobulin light chain
Systemic amyloidosis may often be complicated with haemorrhagic tendency. The causes of this manifestation are factor deficiencies, hyperfibrinolysis and vasculopathy. In order to investigate the role of platelets, if any, we performed platelet aggregation tests with different aggregants in 10 patients with systemic amyloidosis due to familial Mediterranean fever and 10 healthy controls. Platelet aggregation was defective with different aggregants (ADP, epinephrine, collagen) in patients compared with controls. Platelet aggregation tests repeated after desmopressin (DDAVP) administration were normalized. These findings may suggest a role of a platelet aggregation defect in haemorrhagic diathesis complicating systemic amyloidosis. DDAVP may benefit patients with this disease in case of bleeding and before surgical interventions.