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Interleukin‐4 inhibits the production of interleukin‐1 by adult T‐cell leukemia cells
Author(s) -
Mori Naoki,
Shirakawa Fumihiko,
Murakami Shuichi,
Oda Susumu,
Eto Sumiya
Publication year - 1995
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1995.tb01821.x
Subject(s) - neutrophilia , cytokine , interleukin , leukemia , interleukin 3 , immunology , biology , chemistry , cancer research , microbiology and biotechnology , medicine , t cell , interleukin 21 , immune system
Freshly isolated leukemic cells from patients with adult T‐cell leukemia (ATL) produce high levels of interleukin‐1 (IL‐1), which is believed to play an important role in neutrophilia, elevation of C‐reactive protein, osteolytic bone lesions, hypercalcemia, and fever in ATL. However, relatively little is known regarding the regulatory mechanism of IL‐1 production in ATL. Interleukin‐4 (IL‐4) affects the monocytes‐ and neoplastic cells‐mediated cytokine production. In this study, we investigated the effect of IL‐4 on IL‐1 α and IL‐1 β production by ATL cells in vitro. IL‐4 was found to markedly inhibit the release of IL‐1 α and IL‐1 β into the conditioned medium in a dose‐dependent manner. Northern blot analysis of steady‐state IL‐1 mRNA demonstrated that IL‐4 treatment of ATL cells resulted in a reduction of IL‐1 mRNA. These results support the notion that ATL cells spontaneously produce IL‐1 α and IL‐1 β; however, such production can be inhibited by the immunomodulating agent, IL‐4. IL‐4 may play an important regulatory role in the production of IL‐1 in ATL.