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Secretion of leukaemia inhibitory factor after allogeneic bone marrow transplantation: a study of CD4 + and CD8 + TCRαβ + T‐cell clones derived from four leukaemia patients.
Author(s) -
Bruserud Øystein,
Hamann Wilfried,
Pawelec Granham
Publication year - 1995
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1995.tb01776.x
Subject(s) - transplantation , bone marrow transplantation , bone marrow , immunology , cd8 , medicine , antigen
CD4+ and CD8+ TCRαβ+ T‐cell clones were derived from 4 leukaemia patients early (4–6 weeks) after allogeneic bone marrow transplantation. Leukemia inhibitory factor (LIF) secretion in response to the activation signal accessory cells (AC) + phytohaemagglutinin (PHA) was investigated for each individual clone. Only a minority of CD4 + TCRαβ + T‐cell clones secreted LIF in response to AC + PHA, whereas most T‐cell clones were capable of LIF secretion when exogenous interleukin 2 was added together with AC + PHA. LIF secretion could also be demonstrated for CD8+ TCRαβ+ posttransplant T‐cell clones. Thus, posttransplant CD4+ and CD8+ TCRαβ + clonogenic T‐cells are capable of LIF secretion, and LIF secretion may be a T‐cell effector mechanism in graft versus host disease, graft versus leukaemia effects or posttransplant haematopoietic reconstitution.