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Effects of anti‐platelet glycoprotein Ib and /or IIb/IIIa autoantibodies on the size of megakaryocytes in patients with immune thrombocytopenia
Author(s) -
Hasegawa Y.,
Nagasawa T.,
Kamoshita M.,
Komeno T.,
Itoh T.,
Ninomiya H.,
Abe T.
Publication year - 1995
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1995.tb00243.x
Subject(s) - platelet , glycoprotein , autoantibody , platelet membrane glycoprotein , immune thrombocytopenia , antibody , immunology , immune system , megakaryocyte , group a , medicine , biology , microbiology and biotechnology , haematopoiesis , stem cell
To determine whether anti‐platelet autoantibodies react with megakaryocytes, as well as with platelets, in immune thrombocytopenia (ITP), 38 ITP patients were studied. They were classified into four groups; anti‐platelet glycoprotein lb‐positive (group A, n > = 5), anti‐platelet glycoprotein II/b/IIIa‐positive (group B, n = 2), positive to both antibodies (group C, n = 3), and negative to both antibodies (group D, n = 28). The number and size of megakaryocytes in each group were compared. The number of megakaryocytes in groups A, B, C, and D was 12.8 ± 8.9, 75.2, 29.1, and 17.0 ± 21.7/mm 2 , respectively. The mean cytoplasmic area of megakaryocytes in groups A, B, C, and D was 1001 ± 26.3, 1621, 1109, and 1311 ± 235.6/μm 2 , respectively. This finding indicated that, in the presence of anti‐platelet glycoprotein Ib, megakaryocytes were not increased in number and were small in size, whereas, in the presence of anti‐platelet glycoprotein Ilb/IIIa, megakaryocytes were increased in number and in cytoplasmic area. Our study suggested that anti‐platelet glycoprotein Ib may impair platelet production by megakaryocytes in ITP.