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Drug‐induced neutropenia due to direct effects on CFU‐C — Ten years of culture experience
Author(s) -
Irvine Alexandra E.,
French Anne,
Daly Ann,
Ranaghan Lisa,
Morris T. CM.
Publication year - 1994
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1994.tb01280.x
Subject(s) - neutropenia , medicine , intensive care medicine , toxicity
Seventeen patients with suspected drug‐induced neutropenia were referred to our laboratory for investigation within a 10‐year period. In each case, the suspected drugs were incorporated separately into in vitro cultures of the patients' bone marrow. The cultures were performed in triplicate, using multiple controls. In 10 of these patients a drug‐induced inhibition of CFU‐C was demonstrated in vitro. The in vitro culture technique is a valuable investigation in patients with suspected drug‐induced neutropenia, as it can help identify the causative agent, especially in cases of multidrug administration. It also has a useful application in allowing the clinician to predict drugs to which a patient may be unduly sensitive, and prescribe accordingly.