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Immunological recovery after bone marrow transplantation for severe aplastic anaemia: A Brazilian experience
Author(s) -
Souza Maria Helena Ornellas,
Diamond Hilda Rachel,
Silva Maria Luiza Macedo,
Campos Mercia Mendes,
Bouzas Luiz Fernando,
Flowers Mary Evelyn,
Rumjanek Vivian Mary,
Tabak Daniel
Publication year - 1994
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1994.tb00663.x
Subject(s) - immunology , medicine , bone marrow transplantation , bone marrow , cd8 , cirrhosis , lymphocyte , immunodeficiency , transplantation , disease , immune system , gastroenterology
Twenty‐nine patients with severe aplastic anaemia (SAA) were submitted to bone marrow transplantation (BMT) and their immunological recovery analysed. Total lymphocyte counts, estimation of B lymphocytes, T lymphocytes and their subsets, natural‐killer (NK) activity were performed. Cells with the CD8 + phenotype and NK activity were the first signs of immunological recovery, whereas the CD4 + subset recovered later in patients who suffered from acute graft versus host disease (GvHD) and infections. Acute and chronic GvHD, cirrhosis, rejection and HIV viral infection contributed to the persistence of the profound immunodeficiency status observed after BMT. Our results did not differ greatly from the others and confirmed that BMT may be performed in underdeveloped countries despite the difficulties it might pose.