Premium
Cobalamin binding proteins in patients with HIV infection
Author(s) -
Hansen Mads,
Gimsing Peter,
Ingeberg Steen,
Jans Henning,
Nexø Ebba
Publication year - 1992
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1992.tb01590.x
Subject(s) - cobalamin , medicine , human immunodeficiency virus (hiv) , chemistry , endocrinology , population , biochemistry , vitamin b12 , immunology , environmental health
P‐Cobalamins have been reported to be decreased in patients with HIV infection. Because of this, we found it of interest to examine both cobalamin‐saturated binding proteins (holo‐transcobalamin, holo‐TC and holo‐haptocorrin, holo‐HC) and cobalamin unsaturated binding proteins (apo‐transcobalamin, apo‐TC and apo‐haptocorrin, apo‐HC). The results are given as range and (median). Eighteen male HIV‐infected patients with plasma cobalamins below 200 pmol/1 were studied. We found low concentrations of holo‐TC (37–88 (47.5) pmol/1) and holo‐HC (64–184 (135.5) pmol/1). The concentration of apo‐TC and apo‐HC was increased (480–1730 (1025) pmol/1; 70–800 (235) pmol/1). It is concluded that, in HIV‐infected patients, low plasma cobalamin does not reflect a low concentration of transcobalamin or haptocorrin. In 20 HIV‐infected patients and 31 patients with malignant haematological diseases, the TC isopeptide patterns were determined. In the HIV group, an increased frequency of TC isopeptide X was found and the overall distribution of TC isopeptides was significantly different from the reference population (p < 0.05). There was no difference between the group of patients with malignant haematological diseases and the reference group.