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Immune responses and serum levels of cytokines in adult T‐cell leukemia patients and human T‐cell leukemia virus type‐I carriers
Author(s) -
Nakasone Tadashi,
Araki Koichi,
Masuda Masato,
Oshiro Kazuiku,
Arakaki Hitoshi,
Shimoji Tadao,
Shinzato Osamu,
Mimura Goro
Publication year - 1992
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1992.tb00573.x
Subject(s) - immunology , leukemia , peripheral blood mononuclear cell , immunosuppression , immune system , t cell leukemia , interferon , medicine , tumor necrosis factor alpha , biology , virology , biochemistry , in vitro
To find predictive parameters for development and progression of adult T‐cell leukemia (ATL) in human T‐cell leukemia virus type‐I (HTLV‐I) carriers, we investigated cellular immune responses such as mitogenic responses and natural killer activity of the peripheral blood mononuclear cells (PBMC). And serum or plasma levels of cytokines, including tumor‐necrosis factor‐α (TNF‐α), interferon‐γ (IFN‐γ) and immunosuppressive acidic protein (IAP), were also measured in patients with ATL, healthy HTLV‐I carriers and healthy HTLV‐I non‐carriers as controls. Results are as follows: (1) increased spontaneous proliferation and decreased mitogenic responses of PBMC already existed in HTLV‐I carriers; (2) IAP was significantly higher in patients with acute/lymphoma type ATL than in those with chronic/smoldering type, HTLV‐I carriers and HTLV‐I non‐carriers. These results suggest that spontaneous proliferation or mitogenic responses and IAP may be useful parameters for the development and progression of ATL from the carriers. Since HTLV‐I carriers already have various grades of immunosuppression, we should seriously try to prevent further HTLV‐I transmission.